ABSTRACT
Brucellosis is an infectious zoonosis caused by Brucella infection. It is widely prevalent all over the world and brings great losses to the development of public health, animal husbandry and social economy in China. However, the understanding of the specific clinical indications of brucellosis, the virulence factors of Brucella and its pathogenesis is very limited, which leads some limitations in the clinical diagnosis and treatment of brucellosis. Starting from the current epidemic situation of brucellosis, this article focuses on the virulence factors of Brucella and pathogenesis of brucellosis, and comprehensively summarizes the activity track and state of Brucella in the infected organism during the pathogenesis of brucellosis, so as to provide new ideas for the in-depth study of the pathogenesis of brucellosis, and a comprehensive reference for vaccine development and clinical diagnosis and treatment.